Over the last decade or 2 there's been a bit of a renaissance on the hunt for the fountain of youth. A large part of this drive can be laid at the feet of a new paradigm on aging. We no longer look at aging as a strictly time-dependent process. As the science in to … Continue reading Biological age from a picture? Pros, cons, and future directions for Young.AI
A recent study published in The Journals of Gernontology Series A found an association between poor oral health and frailty in the elderly. T he study found that elderly people who had poor status in 3 or more measures of oral frailty(# of natural teeth, chewing ability, tongue pressure, difficulties in eating or swallowing, and … Continue reading Oral health, chronic disease, and longevity
As research in to human aging and the mechanisms behind it grow, there's a need to address the big fat albatross around the neck of gerontology. The albatross is that until we identify some valid biomarkers of human aging, we must rely on the data in animal models and epidemiological research in humans. Currently, there … Continue reading Aging Biomarkers: Am I 7 years older or 10 years younger?
A study recently published in the journal Cell is teeming with incredible insights in to how/why our microbiome evolves with us as we age. There are quite a few key takeaways from this study, which is open access and free to read here. While focus has been on the gut microbiome, other microbial communities throughout … Continue reading A comprehensive review of your aging and evolving gut microbiome
A study I posted recently on the Facebook page generated a decent discussion on how traumatic brain injury promotes a leaky gut. The interesting take-home message from the study is that one long term symptom of traumatic brain injury(TBI) is "leaky gut". The theoretical trek from there is that endotoxin can then cross the gut … Continue reading Could sealing the blood brain barrier and gut really be this easy?
A new study showing the relationship between the circadian clocks and autoimmunity hints at a potential lifestyle fix to help quell the fires of autoimmunity. The study, published in Nature Communications, found that disruption of the circadian clock in myeloid cells by removal of the gene BMAL1, which teams up with CLOCK to function as … Continue reading New study sheds light on circadian rhythms and autoimmunity
If it seems as though research in to aging is exploding right now, that's because it is. Over the last few decades, our paradigm on aging has experienced a pretty substantial shift. What was once believed to be an inevitable process dictated solely on the passage of time and the genetic hand you've been dealt … Continue reading Healthy aging requires proper circadian rhythms
As you're probably aware by now, I fancy myself a test subject in my own longevity experiment. I got my degree in science, I spent 6 years in clinical research at the University of Pennsylvania, and 99.9% of everything I read is either science or science-related. One of the biggest things we need in science … Continue reading Longevity is about more than just aging biomarkers
It's almost dogma in longevity research that caloric restriction will extend your lifespan. Granted, I think everyone agrees that humans won't see the same level of life extension under caloric restriction as mice, primarily because we experience a slower rate of epigenetic drift. It's also unlikely, although still plausible, that humans will spend a large … Continue reading The shocking reasons why calorie restriction may not prolong your life
For those people dealing with gut problems, every day is an adventure. Fortunately, there are a number of dietary approaches that can help a great deal with symptom management. Whether you're talking about the Specific Carbohydrate diet(SCD Diet), low FODMAP diet, or the GAPS diet, many people can do things they weren't previously able to … Continue reading This process is key to regulating gut inflammation