Podcast 5: The importance of cardiometabolic health for optimizing circadian rhythms and reversing chronic disease

If you’re interested in joining the Circadian Retraining Program so you can participate in the Stop Leaky Gut Challenge coming up on Jan 1st, check out the details here.

https://hackyourgut.com/circadian-retraining-program/

  • My story of ignoring cardiometabolic health
  • It’s not about weight
    • Visceral fat vs subcutaneous fat
  • Senescent cells in visceral fat
    • What are senescent cells
      • DDR, telomere attrition, MIDAS
      • SASP
    • Aberrant mitochondrial fat metabolism
    • Senescent cells and circadian disruption
  • Aging, menopause, and visceral fat
    • Contribution of CM dysfunction with accelerated aging
  • Blood glucose regulation and the liver as a central regulator of metabolism
    • CAR increases BG by stimulating the liver to release glucose via glucagon
    • Eating increases glucose absorption, tops of liver glycogen, and excess increases BG
    • Pancreas senses elevated BG and secretes insulin to increase glucose uptake
      • Muscles, liver, and fat
    • Melatonin blocks insulin secretion at night to stabilize BG while we sleep
      • Also resets insulin sensitivity the next day
    • Both cortisol and insulin are important hormonal zeitbgebers
      • They definitely interact
  • Why does blood glucose control matter?
    • Insulin resistance changes the way cells work
      • Plays a role in leaky gut
      • Plays a role in GCR expression in the liver
      • Plays a role in shortening healthspan and lifespan
    • AGEs & gut manifestations of CM dysfunction
      • Methylglyoxal/D-lactate
      • Glyoxa/oxalates
    • Blood glucose is dictated by the output of many hormones including cortisol, glucagon and insulin.
      • A harbinger of problems
  • Many factors go in to regulating your blood glucose levels
    • Circadian rhythms
    • Diet
    • Physical activity (Acute/chronic)
    • Sleep
    • Adiposity
    • Genetics(Most people have thrifty genes)
      • This is last because it’s likely the “least” important
  • Aging, increased intestinal permeability, and longevity
  • Assessing cardiometabolic health
    • HRV, CRF, waist:height ratio, HgA1c, OGTT

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