Optimizing cardiometabolic health to reverse chronic disease

Poor cardiometabolic health is both a consequence and driver of chronic disease. In this episode of the podcast, I cover what cardiometabolic health is and why you should address it to prevent or reverse chronic disease.

In the next episode of the podcast I take a deeper dive in to how metabolic dysfunction drives chronic disease. We’ll focus on gut disorders such as IBS, SIBO, and IBD. You can check that out here.

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  • My story of ignoring cardiometabolic health
  • It’s not about weight
    • Visceral fat vs subcutaneous fat
  • Senescent cells in visceral fat
    • What are senescent cells
      • DDR, telomere attrition, MIDASSASP Aberrant mitochondrial fat metabolismSenescent cells and circadian disruption
  • Aging, menopause, and visceral fat
    • Contribution of CM dysfunction with accelerated aging
  • Blood glucose regulation and the liver as a central regulator of metabolism
    • CAR increases BG by stimulating the liver to release glucose via glucagonEating increases glucose absorption, tops of liver glycogen, and excess increases BGPancreas senses elevated BG and secretes insulin to increase glucose uptake
      • Muscles, liver, and fat Melatonin blocks insulin secretion at night to stabilize BG while we sleep Also resets insulin sensitivity the next day Both cortisol and insulin are important hormonal zeitbgebers They definitely interact
  • Why does blood glucose control matter?
    • Insulin resistance changes the way cells work
      • Plays a role in leaky gutPlays a role in GCR expression in the liverPlays a role in shortening healthspan and lifespan AGEs & gut manifestations of CM dysfunction Methylglyoxal/D-lactateGlyoxa/oxalates Blood glucose is dictated by the output of many hormones including cortisol, glucagon and insulin. A harbinger of problems
  • Many factors go in to regulating your blood glucose levels
    • Circadian rhythmsDietPhysical activity (Acute/chronic)SleepAdiposityGenetics(Most people have thrifty genes)
      • This is last because it’s likely the “least” important
  • Aging, increased intestinal permeability, and longevity
  • Assessing cardiometabolic health
    • HRV, CRF, waist:height ratio, HgA1c, OGTT

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