- What are circadian rhythms?
- Biological functions that vary over a 24 hour period
- Sleep, activity, digestion, immunity, & motivation
- WRT to digestion, enzyme synthesis/secretion, gastric acidity, intestinal permeability, and motility are all circadian
- At the cellular level, circadian rhythms help separate use from repair
- Circadian rhythms help you solve the puzzle that is the environment
- Optimizes physiology to promote success
- For this to work, there need to be multiple inputs and outputs
- We can’t simply rely on the day/night cycle
- Need to be able to shift with food availability
- External cues called zeitgebers help “set” your clock
- Hormones that function to tell time include melatonin, cortisol, insulin, bile, vasopressin, ghrelin
- Circadian rhythms help set your autonomic balance
- Examples of how circadian rhythms work against us
- Improper light exposure and poor sleep
- Ghrelin and eating all of your food in the evening
- Eating late and T2D
- Leaky gut, disturbed bile flow
- Adrenal dysfunction
- Disturbed adrenal function
- Lessons from the calorie-restricted mouse
- CR mice live 20% longer and are time restricted feeding mice
- FAA, eat all of their food in 3 hours, optimal light exposure
- CR and TRE can re-establish youthful circadian gene expression in the liver
- AL feeding causes system-wide disturbances in circadian rhythms
- Where does this leave us?
- Our behavior drives circadian disruption-Social jet lag
- Circadian disruption is associated with all chronic disease
- T2D, CVD, Neurodegenerative, IBS/IBD, arthritis, autoimmune conditions, insomnia,
- We not only need to meet recommendations for a healthy lifestyle, we have to understand that “when matters”
Like this:
Like Loading...
