If you’re sick of dealing with digestive issues and haven’t looked in to the amino acid taurine, I’m here to wake you up.
While you may know taurine from its starring role in energy drinks or the neurological problems experienced by Pottenger’s Cats, it plays a powerful role in the gastrointestinal environment. But how powerful?
Let’s start off by telling you what it does:
- Enhances gastric acid and enzyme production
- Plays a central role in the regulation of inflammation throughout the body
- Regulates the microbiome
- Modulates motility
- Can kick the crap out of H. Pylori…
- And mop up the damage it causes
- Improves fat digestion and fat soluble vitamin absorption
- And so much more…
Certainly one can get enough taurine in their diet. But there are a few groups that should be aware that their lifestyle may lead to a lack of it.
- People eating a lot of fat
- People eating a lot of meat
- Diets high in meat that also eat a lot of soluble fiber
- Those who cook their meat(I’m not telling you not to, jus’ sayin’)
- Vegans(Those poor blokes)
These lifestyle choices can lead down a path where digestive disorders pop up. I have no doubt that the following people would benefit from supplementing with taurine. People with:
- Slow or fast motility
- Low stomach acid
- Fat malabsorption
- Fat soluble vitamin deficiencies
- I could go on…
Before we get in to these lists, let’s look a bit at the history of taurine and how it plays in to its biological effects.
History of taurine
Taurine is the most abundant amino acid in animals, but found sparingly in plants. For the sake of comparison, plants contain about 1/100 the amount found in meat(1).
There is little doubt that taurine is important for animal life. If you’d like to check out the many reasons why, this article is a good start.
Fortunately, animals have a pathway to synthesize it from the amino acids methionine and cysteine if their diet lacks it. Herbivorous animals tend to be better at making it which makes sense if you need it but don’t eat it. Carnivores have a tougher time making it but don’t need to since they eat plenty of it. That puts omnivores somewhere in the middle, and this can cause some problems.
There’s another large difference between herbivores and carnivores that involves taurine worth mentioning. Animals use bile acids to emulsify fat, making it easier to digest. It also plays a major role in the GI environment and composition of bacteria located within.
Taurine in bile acids
Though necessary for proper digestion, bile acids are toxic. To prevent bile acids from damaging your cells, they get conjugated with either glycine or taurine before they get sent to your gall bladder.
The funny thing here is we see another stark contrast between herbivores and carnivores. Healthy herbivores conjugate bile acids with glycine while healthy carnivores conjugate with taurine. A notable exception in herbivores is ruminants, who mostly conjugate with taurine. Guess where that puts us omnivores…You guessed it, right in the middle.
But it’s a little more nuanced than that. All animals studied can conjugate bile acids with either glycine or taurine. In fact, the same enzyme does both(2). Whether an animal conjugates with glycine or taurine comes right down to diet. We don’t have data for herbivores, but in omnivores and carnivores, whether you conjugate with taurine or glycine comes down to the amount of taurine in your diet.
Feed a human ample taurine and they’ll conjugate more bile acids with it. Limit it and they’ll conjugate more with glycine. Feed unlimited amounts of both…you’ll see a large proportion conjugated with taurine(3). It seems taurine must be important in the digestive process. It also seems essential if you’re diet contains meat.
Taurine deficiency in cats
Pottenger’s Cats is an excellent example of what taurine deficiency can do to an animal. It’s also a prime example of how a simple dietary change can cause enormous problems. If you aren’t familiar with Pottenger’s cats, check it out.
Cats need it in their diet because they synthesize it poorly. In Pottenger’s experiments feeding cats different diets, feeding cats cooked meat caused major issues in nearly every system in their body. It also caused major developmental problems in future generations. Cats fed the exact same diet with raw meat instead of cooked flourished, as did their successive generations. The problem is in the physical characteristics of taurine.
Cooking doesn’t damage taurine. But since it’s not bound to other proteins in cells, it floats around in cellular fluids. So if I cut in to a raw steak I’ll break some cells open which will cause a small amount of taurine to leak out. If I grind it in to ground beef, I’ll lose much more. If I cook it, any fluid lost will also contain taurine. Those juices you toss…Bye bye taurine. Overcooking the steak till it’s like shoe leather…Bye bye taurine.
Is taurine need diet dependent?
So a quick rundown…Animals that eat meat need taurine. Animals that eat raw meat get enough, animals that eat cooked meat may not. Well, at least animals that have poor synthesis of it. Like cats.
But where do we lie? Truth is, we have no idea. Given the relationship between taurine and the amount of meat in an animals diet, there’s something there. I think it’s safe to say that tauro-conjugated bile acids have a significant impact on the GI environment.
While bile acids are conjugated in your liver and stored in the gallbladder, once they hit your intestine they’re free game. Bacteria located throughout your digestive tract deconjugate bile acids as they pass by. This leaves potentially damaging bile acids in your gut, it also leaves a lot of free taurine.
This taurine gets circulated through your digestive tract all day long as part of the enterohepatic circulation. Free taurine that can modulate the environment in more ways than 1. So I finally give you the 10 reasons why you need taurine for amazing gut health…
I know, that took a while
10 ways taurine may improve gut health
1)It may enhance gastric acid secretion
Obviously a carnivorous diet contains a lot more protein than an herbivorous one. If you’re in tune with my line of thinking, you’re thinking taurine may have an effect on digestive enzyme output. In a study with rats, it was shown to increase gastric acid secretion(4). Another study in dogs found it caused cells in the stomach to secrete more gastric acid and pepsin, but only when stimulated to do so(5). In other words, they have better gastric output when they eat.
There is no data in humans, and this evidence is far from adequate to make a hard conclusion on the effect of taurine in gastric secretions. Coupled with the historical aspects of taurine in carnivores, it makes sense that there are components found only in meat that promote protein digestion. And it makes no sense for plants to cause the same gastric response as meat because plants don’t contain a lot of protein. It seems taurine is a good candidate.
2)Tauro-conjugated bile acids may be better for fat absorption
Tauro-conjugated bile acids are more water-soluble than their glycine conjugated brethren. This causes them to stick around in the GI tract for longer. This leads to a larger bile acid pool size(6). The primary role of bile acids is to enhance the digestion and absorption of fat. A larger bile acid pool means you’ll be better at both.
Tauro-conjugated bile acids are also less likely to damage cells of the intestine, called enterocytes. Enterocytes get damaged when bile acids passively enter them. Since tauro-conjugated bile acids are water soluble, they can’t enter enterocytes in the ileum unless deconjugated by bacteria. Enterocytes in the ileum have bile acid receptors that take them up and recycle them to the liver, but that isn’t a damaging process.
Glycine conjugated bile acids, by being less water soluble, get absorbed passively throughout the digestive tract. This means that the bile acid pool is smaller and the risk for damage to enterocytes greater. Fortunately, glycine conjugators eat more soluble fiber, which is protective to enterocytes. Although, this fiber may have a negative impact on meat heavy diets.
3)It enhances fat-soluble vitamin absorption
In addition to improving fat digestion and absorption, bile acids enhance the absorption of fat-soluble vitamins. Therefore, an increase in bile acid pool size improves the absorption of fat soluble vitamins. Fat malabsorption is common in digestive disorders, particularly IBD. Poor fat soluble vitamin absorption also comes with the territory.
Taurine may also act as an independent carrier of fat soluble vitamins(7). It forms conjugates with many fat soluble molecules, making them more water soluble. In the eye, it aids in the transport of vitamin A(retinol), a fat soluble vitamin(8). This same process may occur in other parts of the body, including the gut.
4)Meat-heavy diets may require more tauro-conjugated bile acids
If it didn’t hit you in the face earlier, I’ll hit you with it again. It’s extremely significant that carnivores conjugate their bile acids exclusively with taurine. Tauro-conjugated bile acids appear to be better emulsifiers of fat because they are more stable at the pH in the duodenum(9).
It makes sense that some component of a carnivorous diet would make digesting and absorbing fats more efficient. Carnivorous diets tend to be higher in fat because animals store more fat than plants do. Sure, nowadays you can get your hands on a 32oz jar of coconut oil, but an herbivore probably doesn’t eat that much fat in a month.
The primary conjugation of bile acids with taurine in carnivores implies that a diet with more meat requires more. People who try to heal their gut with the SCD or low FODMAP diet have to eat more meat because processed foods are out. Assuming they are cooking their meat, supplemental taurine may be necessary for these diets.
Increased gastric acid secretion and better fat absorption from taurine are 2 pretty important factors that promote the digestion of meat. Since humans have a pathway to synthesize taurine, whether you need it in your diet or not may depend on other factors. One of the factors that decreases synthesis happens to be a widely recommended component of a healthy diet.
5)A diet high in soluble fiber decreases synthesis
There is zero disagreement on the benefit of soluble fiber in the diet. Bacteria in your gut ferment soluble fiber in to short chain fatty acids that are preferential fuel for enterocytes(10). SCFAs also reduce intestinal permeability and inflammation. A diet high in soluble fiber also improves blood cholesterol and glucose levels(11).
But it’s not all cupcakes and roses with soluble fiber. Soluble fiber intake reduces taurine synthesis in the liver(12, 13). This causes an increase in the ratio of glycine/taurine conjugated bile acids. In an herbivorous diet this has no major consequences, but in a diet that also contains meat, it could be problematic. In a diet with reduced intake due to cooking or processing, it could cause major issues.
Again, I like to go back to what this means from an evolutionary perspective. Since a diet containing meat has more taurine, it may be a protective factor in animals that eat meat. In the same way, soluble fiber may do the same for a plant-based diet. This could offset the damage from glycine conjugated bile acids. But you don’t have to choose between meat or veggies. It appears you can have your cake and eat it too.
6)Supplementing with it may offset the negative effects of a high soluble fiber diet
Even though soluble fiber lowers taurine synthesis, there’s more than one way to skin a cat. The enzyme that conjugates bile acids prefers to tauro-conjugated bile acids.
When you supplement with taurine or eat more, you’ll conjugate your bile acids with it. Increasing intake corrects for decreased synthesis in a high soluble fiber diet(14). If there’s taurine present, whether synthesized or eaten, your liver conjugates bile acids with it.
In the grand scheme of things, both meat and fiber are primary components of a healthy diet. This doesn’t mean there aren’t drawbacks. The effects of loss from cooking or processing meat is amplified if you eat a diet high in soluble fiber.
By taking supplemental taurine, you combine the protective effects of soluble fiber with it. You can also reduce loss by cooking meats in stews or pouring the juices lost to cooking over the meat.
7)It regulates the microbiome
Soluble fiber isn’t the only game in town when it comes to increasing SCFA production. Taurine increases SCFA production and reduces lipopolysaccharide(LPS) in the gut(15). LPS is inflammatory, so decreasing it has beneficial effects on gut health.
In the same study, it also reduced levels of helicobacter species. Helicobacter Pylori(H. Pylori) is the opportunistic bacteria associated with gastric and duodenal ulcers. Helicobacter species do not tolerate bile, so higher levels of bile also inhibit helicobacter growth. This effect is greater for glycine and mixed conjugates of bile than for tauro-conjugates(16).
How taurine regulates the microbiome
Taurine also has a direct effect on the microbiome. Inflammasomes initiate inflammatory cascades and play a large role in host immunity. A specific inflammasome, known as the NLRP6 inflammasome, regulates the the GI environment.
Loss of the NLRP6 inflammasome leads to dysbiosis and chronic inflammation in the GI tract. In addition to the effect on inflammatory signaling, the NLRP6 inflammasome is important for mucus secretion from goblet cells, which prevents bacteria from interacting with the intestinal wall.
Taurine activates the NLRP6 inflammasome(19). This has many effects on the microbiome due to changes in the GI environment. Loss of the inflammasome promotes dysbiosis and dysbiosis disrupts inflammasome signaling.
Specifically, it increases histamine production and decreases histamine degradation. These 2 factors promote the dysbiotic environment by blocking inflammasome signaling. Taurine can rescue inflammasome signaling and restore the healthy microbiome. We covered this in a blog you can check out here.
8)It may help heal H. Pylori-induced ulcers
H. Pylori is found in 50% of the World’s population, but causes no problems in 80% of the people who have it. In some people, H. Pylori causes gastritis and ulcers in the stomach or duodenum. One of the ways it does this is by breaking down gastric urease.
When H. Pylori breaks down urea, it releases ammonia and carbon dioxide. This ammonia neutralizes stomach acid and provides an environment where H. Pylori can colonize. It also has the unfortunate side effect of causing major bloating in the stomach and damage to the lining.
The release of ammonia also has another effect: it causes ulcers. When H. Pylori colonizes the stomach, it attracts neutrophils. Neutrophils are immune cells sent to contain the colonization. They enter the stomach and secrete hypochlorous acid to kill invaders. When hypochlorous acid reacts with ammonia, it creates monochloramine. Monochloramine irritates the stomach and impairs ulcer healing.
Taurine scavenges monochloramine by binding to it. This prevents the damage caused by monochloramine and speeds up the healing of ulcers(20). Unfortunately, it also means that a person with an active H. Pylori problem likely needs more taurine.
When taurine binds to monochloramine, it isn’t absorbed. This means it isn’t used to conjugate bile acids or for any of the other systems that rely on it. This includes the nervous and cardiovascular systems.
9)It may help resolve gut inflammation
Neutrophils are highly mobile immune cells that migrate to the site of inflammation or infection. Once in an area of active inflammation, neutrophils undergo activation and begin engulfing pathogens. They also secrete inflammatory cytokines to recruit more immune cells to the area.
Taurine is abundant in neutrophils and plays a large role in managing inflammation by combining with hypochlorous acid to form tauro-chloramines. Hypochlorous acid on it’s own is damaging to cells while taurine chloramine is not.
With inadequate taurine, neutrophils secrete the more damaging hypochlorous acid which reacts with ammonia. It also damages healthy tissue.
Once neutrophils do their job at the site of an infection, they undergo something called apoptosis. Apoptosis is programmed cell death and plays a key role in limiting inflammation. When neutrophils burst open, tauro-chloramine gets released. Apoptosis is necessary for the resolution of inflammation and attracts macrophages to the area. The macrophages help finish cleaning up the mess.
Tauro-chloramine released from neutrophils promotes this cleaning up process(21). It decreases inflammatory mediators secreted by macrophages(22) and acts as an antioxidant to reduce collateral damage(23). This helps resolve inflammation and lowers oxidative stress(24). These effects coupled with the anti-bacterial effects of tauro-chloramine help resolve inflammation and prevent it from becoming chronic.
Tauro-chloramine also promotes apoptosis of cancer cells. Hypochlorous acid, in contrast, causes necrosis or cell death due to oxidative damage(25). This subtle difference between apoptosis and necrosis increases the inflammatory response.
10)It may normalize slow or fast GI motility
Many digestive disorders present with altered GI motility. For example, fast motility is common in people with diarrhea while slow motility is common in people with constipation. The cause of the change in motility in both instances is unknown, but recent evidence shows taurine may help in both instances.
In a study where low and high contractile states were induced in enterocytes, taurine normalized both states. When a low contractile state was induced, taurine stimulated contractility. In contrast, when a high contractile state was induced taurine inhibited contractility(26).
This study shows that taurine may play a role in regulating GI motility homeostasis. While the exact mechanisms are unknown, researchers believe that taurine helps via the regulation of calcium channels, which regulate the contractile state. Deconjugation of bile acids by bacteria may release free taurine. This could help regulate motility.
Taurine may be a valuable supplement for people with digestive disorders including IBS and SIBO. It wears many hats including conjugator of bile acids, regulator of the intestinal environment, and modulator of intestinal motility. Taurine is also useful as an adjunct to other therapies including antibiotic use. It may help maintain a healthy microbiome and prevent post-antibiotic dysbiosis.
It is important to point out that people with active IBD flares may not do so well with taurine. This isn’t to say that taurine won’t do all the above, it will. But people with IBD, specifically ulcerative colitis, don’t do well with sulfur-based amino acids, and taurine is one of them.
Is taurine the problem, per se? Probably not. It’s that having more sulfur in the colon increased sulfate reducers which in turn increases something called hydrogen sulfide(H2S).
H2S can erode the mucus layer at high levels, so those with higher H2S producers in their gut should work with lower doses. That being said, most people are still probably getting inadequate amounts of taurine.
Taurine loss due to cooking and processing of meat may be physiologically relevant in the human diet. Taurine conjugation of bile acids is dependent on the amount of taurine in the diet. Since taurine in meat is unbound, significant taurine is lost in fluids. Most carnivores and omnivores are protected from this loss as they don’t process or cook meat. Humans are the sole species that cooks the majority of their meat.
The need for taurine in the diet is dependent on an animals ability to synthesize it. Herbivores tend to be good at taurine synthesis…carnivores not so much. This is likely due to the availability of taurine in a carnivorous diet reducing the need for synthesis.
There is definitely something to this dichotomy between herbivores and carnivores. It’s also telling that herbivores tend to conjugate their bile acids with glycine while carnivores tend to conjugate their bile acids with taurine. While there is no data on herbivores, taurine conjugation of bile acids seems to be the preferred method. With enough taurine in the diet, taurine conjugation predominates. Glycine availability has no effect.
But where do we fall on this spectrum? Our ancestral lineage follows the line of an herbivore that began to eat meat. Maybe our ability to synthesize taurine isn’t that bad, maybe it is. The only study on the subject found human taurine synthesis to be a fraction of of that seen in rats, cats, and other primates(27). But there are severe methodological problems with this study.
Research may never give a concrete answer to the human need for dietary taurine. Fortunately, taurine is water soluble so sane levels of supplementation aren’t toxic. It’s also fairly cheap and easy to find, so there’s little risk or cost to trying it. Give it a try and let me know how it works out for you.